From To Reaction Type Controller Control Type Cell Type PMIDs Genes Drugs Diseases Summary rifampin NR1I2 Activation null, neoplastic cell 15319341 NR1I2 rifampin rifampin activates NR1I2. NR1I2 CYP3A4 Activation neoplastic cell 15319341, 11723248, 10935643 CYP3A4, NR1I2 NR1I2 activates CYP3A4. ergocalciferol VDR Activation null, neoplastic cell 12969965 VDR ergocalciferol ergocalciferol activates VDR. NR1I2 ABCB1 Activation neoplastic cell 11297522 ABCB1, NR1I2 NR1I2 activates ABCB1. etoposide NR1I2 Activation neoplastic cell 12181418 NR1I2 etoposide etoposide activates NR1I2. xenobiotics NR1I2 Activation null, neoplastic cell 17279585 NR1I2 xenobiotics activates NR1I2. dexamethasone NR1I2 Activation null, neoplastic cell 22994453 NR1I2 dexamethasone dexamethasone activates NR1I2. VDR CYP3A4 Activation neoplastic cell 12969965, 11991950, 11723248, 9145912 CYP3A4, VDR VDR activates CYP3A4. NR1I2 CYP3A5 Activation neoplastic cell 22994453 CYP3A5, NR1I2 NR1I2 activates CYP3A5. etoposide etoposide catechol Biochemical Reaction CYP3A4, CYP3A5 Gene neoplastic cell 15319341, 8114683, 2167725 etoposide Biochemical reaction from etoposide to etoposide catechol. This interaction can be catalyzed by CYP3A4 or CYP3A5. quinone glutathione conjugate Biochemical Reaction GSTP1, GSTT1 Gene neoplastic cell 16841962, 10900222, 1315544 Biochemical reaction from etoposide quinone to glutathione conjugate. This interaction can be catalyzed by GSTP1 or GSTT1. etoposide catechol quinone Biochemical Reaction MPO Gene neoplastic cell 16841962, 15319341, 11691792, 2167725, 2972290, 2854106 Biochemical reaction from etoposide catechol to etoposide quinone. This interaction is catalyzed by MPO. etoposide etoposide glucuronide Biochemical Reaction UGT1A1 Gene neoplastic cell 12695347 etoposide Biochemical reaction from etoposide to etoposide glucuronide. This interaction is catalyzed by UGT1A1. etoposide quinone Biochemical Reaction PTGS1, PTGS2 Gene neoplastic cell 3117357, 3006680 etoposide Biochemical reaction from etoposide to etoposide quinone. This interaction can be catalyzed by PTGS1 or PTGS2. quinone TOP2B Inhibition neoplastic cell 24766193 TOP2B etoposide quinone inhibits TOP2B. etoposide catechol TOP2A Inhibition neoplastic cell 23863110, 17361331 TOP2A etoposide catechol inhibits TOP2A. etoposide TOP2B Inhibition neoplastic cell 30006062 TOP2B etoposide etoposide inhibits TOP2B. quinone TOP2A Inhibition neoplastic cell 27533850, 21595477, 17361331, 17578914, 11531262, 9748598, 2934259 TOP2A etoposide quinone inhibits TOP2A. etoposide TOP2A Inhibition neoplastic cell 29514855, 17578914 TOP2A etoposide etoposide inhibits TOP2A. etoposide glucuronide etoposide glucuronide Transport ABCC3 Gene neoplastic cell, null 20028753, 11581266 Transport from etoposide glucuronide to etoposide glucuronide. This interaction is catalyzed by ABCC3. etoposide etoposide Transport ABCB1, ABCC3 Gene neoplastic cell, null 20309692, 20028753, 11581266 etoposide Transport from etoposide to etoposide. This interaction can be catalyzed by ABCB1 or ABCC3. glutathione conjugate glutathione conjugate Transport ABCC1 Gene neoplastic cell, null 9685354, 8640791, 7809167, 7954421, 7915193, 7916458, 8275468 Transport from glutathione conjugate to glutathione conjugate. This interaction is catalyzed by ABCC1.