From To Reaction Type Controller Control Type Cell Type PMIDs Genes Drugs Diseases Summary cotinine norcotinine Biochemical Reaction CYP2A6 Gene hepatocyte 16359169, 9010629 Biochemical reaction from cotinine to norcotinine. This interaction is catalyzed by CYP2A6. nicotine nicotine iminium ion Biochemical Reaction CYP2A13, CYP2A6, CYP2B6 Gene hepatocyte 25293881, 16359169, 16272956, 15735609, 15528319, 15592323, 15940289, 15564629, 15475735, 11207029, 11180041, 10999944, 10544257, 10350185, 8937855 nicotine Biochemical reaction from nicotine to nicotine iminium ion. This interaction can be catalyzed by CYP2B6, CYP2A13 or CYP2A6. nicotine n-oxide nicotine Biochemical Reaction hepatocyte 28290528, 4753093 nicotine Biochemical reaction from nicotine n-oxide to nicotine. cotinine 3-hydroxycotinine Biochemical Reaction CYP2A13, CYP2A6 Gene hepatocyte 16188955, 16359169, 15528319, 8627511 Biochemical reaction from cotinine to 3-hydroxycotinine. This interaction can be catalyzed by CYP2A6 or CYP2A13. cotinine cotinine glucuronide Biochemical Reaction UGT1A1, UGT1A4, UGT1A9, UGT2B10 Gene hepatocyte 17576790, 12433823 Biochemical reaction from cotinine to cotinine glucuronide. This interaction can be catalyzed by UGT1A9, UGT2B10, UGT1A4 or UGT1A1. nicotine iminium ion cotinine Biochemical Reaction AOX1 Gene hepatocyte 25293881, 19184652 Biochemical reaction from nicotine iminium ion to cotinine. This interaction is catalyzed by AOX1. 3-hydroxycotinine 3-hydroxycotinine glucuronide Biochemical Reaction UGT1A4, UGT1A9, UGT2B15, UGT2B4, UGT2B7 Gene hepatocyte 15470160 Biochemical reaction from 3-hydroxycotinine to 3-hydroxycotinine glucuronide. This interaction can be catalyzed by UGT2B7, UGT2B4, UGT1A9, UGT1A4 or UGT2B15. nicotine nicotine n-oxide Biochemical Reaction FMO3 Gene hepatocyte 28290528, 1446003, 3380084 nicotine Biochemical reaction from nicotine to nicotine n-oxide. This interaction is catalyzed by FMO3. cotinine 5-hydroxycotinine Biochemical Reaction CYP2A13, CYP2A6 Gene hepatocyte 16359169 Biochemical reaction from cotinine to 5-hydroxycotinine. This interaction can be catalyzed by CYP2A6 or CYP2A13. nornicotine norcotinine Biochemical Reaction hepatocyte 9010629 Biochemical reaction from nornicotine to norcotinine. cotinine cotinine n-oxide Biochemical Reaction hepatocyte 21452992 Biochemical reaction from cotinine to cotinine n-oxide. nicotine nicotine glucuronide Biochemical Reaction UGT1A4, UGT2B10, UGT2B7 Gene hepatocyte 17576790, 12433823 nicotine Biochemical reaction from nicotine to nicotine glucuronide. This interaction can be catalyzed by UGT2B10, UGT1A4 or UGT2B7. nicotine nornicotine Biochemical Reaction CYP2A13, CYP2A6, CYP2B6 Gene hepatocyte 16135656 nicotine Biochemical reaction from nicotine to nornicotine. This interaction can be catalyzed by CYP2B6, CYP2A13 or CYP2A6.