From To Reaction Type Controller Control Type Cell Type PMIDs Genes Drugs Diseases Summary SN-38 sn-38 glucuronide Biochemical Reaction UGT1A1, UGT1A9 Gene hepatocyte 23386248, 18797458, 12960109, 12730278, 12181437, 11990381, 9466980 SN-38 Diarrhea,Neutropenia Biochemical reaction from SN-38 to SN-38 glucuronide. This interaction can be catalyzed by UGT1A1 or UGT1A9. irinotecan irinotecan M4 Biochemical Reaction CYP3A4, CYP3A5 Gene hepatocyte 11602529, 10815927 irinotecan Diarrhea,Neutropenia Biochemical reaction from irinotecan to irinotecan M4. This interaction can be catalyzed by CYP3A5 or CYP3A4. irinotecan SN-38 Biochemical Reaction CES1, CES2 Gene hepatocyte 20653675, 17640957, 12960109 SN-38, irinotecan Diarrhea,Neutropenia Biochemical reaction from irinotecan to SN-38. This interaction can be catalyzed by CES2 or CES1. irinotecan SN-38 Biochemical Reaction BCHE, CES1, CES2 Gene null 20653675, 12960109, 10197614 SN-38, irinotecan Diarrhea,Neutropenia Biochemical reaction from irinotecan to SN-38. This interaction can be catalyzed by CES2, CES1 or BCHE. irinotecan apc Biochemical Reaction CYP3A4 Gene hepatocyte 11602529, 10815927 irinotecan Diarrhea,Neutropenia Biochemical reaction from irinotecan to APC. This interaction is catalyzed by CYP3A4. irinotecan npc Biochemical Reaction CYP3A4, CYP3A5 Gene hepatocyte 11602529, 10815927 irinotecan Diarrhea,Neutropenia Biochemical reaction from irinotecan to NPC. This interaction can be catalyzed by CYP3A5 or CYP3A4. npc SN-38 Biochemical Reaction CES1, CES2 Gene hepatocyte 9655905 SN-38 Diarrhea,Neutropenia Biochemical reaction from NPC to SN-38. This interaction can be catalyzed by CES1 or CES2. irinotecan SN-38 Biochemical Reaction CES1, CES2 Gene enterocyte 20653675, 12960109 SN-38, irinotecan Diarrhea,Neutropenia Biochemical reaction from irinotecan to SN-38. This interaction can be catalyzed by CES1 or CES2. SN-38 sn-38 glucuronide Biochemical Reaction UGT1A1, UGT1A10, UGT1A6, UGT1A7 Gene enterocyte 23963147, 23386248, 19696792, 12893990 SN-38 Diarrhea,Neutropenia Biochemical reaction from SN-38 to SN-38 glucuronide. This interaction can be catalyzed by UGT1A6, UGT1A7, UGT1A1 or UGT1A10. SN-38 Diarrhea Leads To enterocyte, null 23963147, 23386248 SN-38 Diarrhea,Neutropenia SN-38 leads to Diarrhea. SN-38 Neutropenia Leads To null 23386248, 18797458 SN-38 Diarrhea,Neutropenia SN-38 leads to Neutropenia. SN-38 SN-38 Transport SLCO1B1 Gene null, hepatocyte 15608127, 11489791 SN-38 Diarrhea,Neutropenia Transport from SN-38 to SN-38. This interaction is catalyzed by SLCO1B1. irinotecan irinotecan Transport ABCB1, ABCC2 Gene hepatocyte, enterocyte 18418374, 14646693, 11489791 irinotecan Diarrhea,Neutropenia Transport from irinotecan to irinotecan. This interaction can be catalyzed by ABCC2 or ABCB1. SN-38 SN-38 Transport ABCB1, ABCC2, ABCC5, ABCG2 Gene hepatocyte, enterocyte 26352872, 18418374, 12810652, 11489791 SN-38 Diarrhea,Neutropenia Transport from SN-38 to SN-38. This interaction can be catalyzed by ABCC5, ABCG2, ABCB1 or ABCC2. SN-38 SN-38 Transport ABCC1, ABCG1 Gene hepatocyte, null 26352872, 11489791, 10220571 SN-38 Diarrhea,Neutropenia Transport from SN-38 to SN-38. This interaction can be catalyzed by ABCG1 or ABCC1. sn-38 glucuronide sn-38 glucuronide Transport ABCC2 Gene hepatocyte, enterocyte 18418374, 11489791 Diarrhea,Neutropenia Transport from SN-38 glucuronide to SN-38 glucuronide. This interaction is catalyzed by ABCC2.