a66
c75
c0f
b56
a66
a66
a66
c0f
a66
c0f
a66
c0f
a66
c0f
b56
c0f
a66
ea2
c99
fe6
a66
a66
ea2
a66
a66
f1b
c0f
a66
a66
a66
a66
a66
c75
c75
a66
a66
b81
dcb
baa
c0f
c0f
fa2
dcb
b81
be1
baa
c9b
d2d
c9a
10839993
PubMed
Evidence that metformin exerts its anti-diabetic effects through inhibition of complex 1 of the mitochondrial respiratory chain.
Biochem J
2000
Owen MR
Doran E
Halestrap AP
22869320
PubMed
Regulation of insulin sensitivity by serine/threonine phosphorylation of insulin receptor substrate proteins IRS1 and IRS2.
Diabetologia
2012
Copps KD
White MF
17476361
PubMed
Effect of genetic variation in the organic cation transporter 1 (OCT1) on metformin action.
J Clin Invest
2007
Shu Y
Sheardown SA
Brown C
Owen RP
Zhang S
Castro RA
Ianculescu AG
Yue L
Lo JC
Burchard EG
Brett CM
Giacomini KM
21349801
PubMed
Metformin: its emerging role in oncology.
Hormones (Athens)
2011
Micic D
Cvijovic G
Trajkovic V
Duntas LH
Polovina S
10617608
PubMed
Dimethylbiguanide inhibits cell respiration via an indirect effect targeted on the respiratory chain complex I.
J Biol Chem
2000
El-Mir MY
Nogueira V
Fontaine E
Avéret N
Rigoulet M
Leverve X
16952573
PubMed
Neither LKB1 nor AMPK are the direct targets of metformin.
Gastroenterology
2006
Hardie DG
21920351
PubMed
Metformin suppresses pregnane X receptor (PXR)-regulated transactivation of CYP3A4 gene.
Biochem Pharmacol
2011
Krausova L
Stejskalova L
Wang H
Vrzal R
Dvorak Z
Mani S
Pavek P
21470407
PubMed
Understanding the benefit of metformin use in cancer treatment.
BMC Med
2011
Dowling RJ
Goodwin PJ
Stambolic V
19629071
PubMed
The LKB1-AMPK pathway: metabolism and growth control in tumour suppression.
Nat Rev Cancer
2009
Shackelford DB
Shaw RJ
11602624
PubMed
Role of AMP-activated protein kinase in mechanism of metformin action.
J Clin Invest
2001
Zhou G
Myers R
Li Y
Chen Y
Shen X
Fenyk-Melody J
Wu M
Ventre J
Doebber T
Fujii N
Musi N
Hirshman MF
Goodyear LJ
Moller DE
19106626
PubMed
The antidiabetic drug metformin suppresses HER2 (erbB-2) oncoprotein overexpression via inhibition of the mTOR effector p70S6K1 in human breast carcinoma cells.
Cell Cycle
2009
Vazquez-Martin A
Oliveras-Ferraros C
Menendez JA
21186350
PubMed
Common variants near ATM are associated with glycemic response to metformin in type 2 diabetes.
Nat Genet
2011
Zhou K
Bellenguez C
Spencer CC
Bennett AJ
Coleman RL
Tavendale R
Hawley SA
Donnelly LA
Schofield C
Groves CJ
Burch L
Carr F
Strange A
Freeman C
Blackwell JM
Bramon E
Brown MA
Casas JP
Corvin A
Craddock N
Deloukas P
Dronov S
Duncanson A
Edkins S
Gray E
Hunt S
Jankowski J
Langford C
Markus HS
Mathew CG
Plomin R
Rautanen A
Sawcer SJ
Samani NJ
Trembath R
Viswanathan AC
Wood NW
Harries LW
Hattersley AT
Doney AS
Colhoun H
Morris AD
Sutherland C
Hardie DG
Peltonen L
McCarthy MI
Holman RR
Palmer CN
Donnelly P
Pearson ER
20615625
PubMed
Ionizing radiation activates AMP-activated kinase (AMPK): a target for radiosensitization of human cancer cells.
Int J Radiat Oncol Biol Phys
2010
Sanli T
Rashid A
Liu C
Harding S
Bristow RG
Cutz JC
Singh G
Wright J
Tsakiridis T
20859243
PubMed
Role of organic cation transporter 3 (SLC22A3) and its missense variants in the pharmacologic action of metformin.
Pharmacogenet Genomics
2010
Chen L
Pawlikowski B
Schlessinger A
More SS
Stryke D
Johns SJ
Portman MA
Chen E
Ferrin TE
Sali A
Giacomini KM
21163246
PubMed
Regulation of hepatic metabolism by AMPK.
J Hepatol
2011
21163246
PubMed
Regulation of hepatic metabolism by AMPK.
J Hepatol
2011
Foretz M
Viollet B
22869320
PubMed
Regulation of insulin sensitivity by serine/threonine phosphorylation of insulin receptor substrate proteins IRS1 and IRS2.
Diabetologia
2012
Copps KD
White MF