From To Reaction Type Controller Control Type Cell Type PMIDs Genes Drugs Diseases N,N,O-tridesmethyl-tramadol (M4) N,N,O-tridesmethyl-tramadol conjugates Biochemical Reaction hepatocyte N,N-didesmethyl-tramadol (M3) N,N,O-tridesmethyl-tramadol (M4) Biochemical Reaction hepatocyte 11454734 N,O-didesmethyl-tramadol (M5) N,N,O-tridesmethyl-tramadol (M4) Biochemical Reaction hepatocyte 11454734 N,O-didesmethyl-tramadol (M5) N,O-didesmethyl-tramadol conjugates Biochemical Reaction hepatocyte 11454734 N-desmethyl-tramadol (M2) N,N-didesmethyl-tramadol (M3) Biochemical Reaction CYP2B6,CYP3A4 Catalysis hepatocyte 11454734 CYP2B6, CYP3A4 N-desmethyl-tramadol (M2) N,O-didesmethyl-tramadol (M5) Biochemical Reaction CYP2D6 Catalysis hepatocyte 11454734 CYP2D6 O-desmethyl-tramadol (M1) N,O-didesmethyl-tramadol (M5) Biochemical Reaction CYP2B6,CYP3A4 Catalysis hepatocyte 11454734 CYP2B6, CYP3A4 O-desmethyl-tramadol (M1) O-desmethyl-tramadol glucuronide Biochemical Reaction UGT1A8,UGT2B7 Catalysis hepatocyte 20797434 UGT1A8, UGT2B7 tramadol N-desmethyl-tramadol (M2) Biochemical Reaction CYP2B6,CYP3A4 Catalysis hepatocyte 11454734 CYP2B6, CYP3A4 tramadol tramadol O-desmethyl-tramadol (M1) Biochemical Reaction CYP2D6 Catalysis hepatocyte 11454734 CYP2D6 tramadol N,N,O-tridesmethyl-tramadol conjugates N,N,O-tridesmethyl-tramadol conjugates Transport hepatocyte N,O-didesmethyl-tramadol conjugates N,O-didesmethyl-tramadol conjugates Transport hepatocyte O-desmethyl-tramadol (M1) O-desmethyl-tramadol (M1) Transport SLC22A1 Catalysis hepatocyte 21562485 SLC22A1 O-desmethyl-tramadol (M1) O-desmethyl-tramadol (M1) Transport hepatocyte 21562485 O-desmethyl-tramadol glucuronide O-desmethyl-tramadol glucuronide Transport ABCC2 Catalysis hepatocyte 21562485 ABCC2 tramadol tramadol Transport hepatocyte tramadol