From To Reaction Type Controller Control Type Cell Type PMIDs Genes Drugs Diseases Summary leucovorin TYMS Activation malignant cell 15638735, 12724731 TYMS leucovorin leucovorin activates TYMS. proteins methylated proteins Biochemical Reaction methyl transferases Gene Group malignant cell 19812215 Biochemical reaction from proteins to methylated proteins. This interaction is catalyzed by methyl transferases. 5,10-methylenetetrahydrofolate dihydrofolic acid Biochemical Reaction TYMS Gene malignant cell 19812215, 19902562, 12604405, 12084458, 11986237 Biochemical reaction from 5,10-methylenetetrahydrofolate to dihydrofolic acid. This interaction is catalyzed by TYMS. adenosine monophosphate adenosine diphosphate Biochemical Reaction malignant cell 12106498 Biochemical reaction from adenosine monophosphate to adenosine diphosphate. inosine monophosphate adenosine monophosphate Biochemical Reaction malignant cell 12106498 Biochemical reaction from inosine monophosphate to adenosine monophosphate. deoxyuridine monophosphate deoxythymidine monophosphate Biochemical Reaction TYMS Gene malignant cell 16098809 Biochemical reaction from deoxyuridine monophosphate to deoxythymidine monophosphate. This interaction is catalyzed by TYMS. inosine hypoxanthine Biochemical Reaction malignant cell 12106498 Biochemical reaction from inosine to hypoxanthine. 5,10-methylenetetrahydrofolate 5,10-methenyltetrahydrofolate Biochemical Reaction MTHFD1 Gene malignant cell 19812215, 14647408 Biochemical reaction from 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate. This interaction is catalyzed by MTHFD1. adenosine diphosphate adenosine triphosphate Biochemical Reaction malignant cell 12106498 Biochemical reaction from adenosine diphosphate to adenosine triphosphate. adenosine inosine Biochemical Reaction ADA Gene malignant cell 12106498 adenosine Biochemical reaction from adenosine to inosine. This interaction is catalyzed by ADA. tetrahydrofolic acid 10-formyltetrahydrofolate Biochemical Reaction MTHFD1 Gene malignant cell 19812215 Biochemical reaction from tetrahydrofolic acid to 10-formyltetrahydrofolate. This interaction is catalyzed by MTHFD1. 5,10-methenyltetrahydrofolate 10-formyltetrahydrofolate Biochemical Reaction MTHFD1 Gene malignant cell 19812215, 14647408 Biochemical reaction from 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate. This interaction is catalyzed by MTHFD1. inosine monophosphate inosine Biochemical Reaction malignant cell 12106498 Biochemical reaction from inosine monophosphate to inosine. 5,10-methenyltetrahydrofolate leucovorin Biochemical Reaction MTHFS Gene malignant cell 19812215, 3801490 Biochemical reaction from 5,10-methenyltetrahydrofolate to leucovorin. This interaction is catalyzed by MTHFS. adenosine monophosphate adenosine Biochemical Reaction NT5E Gene malignant cell 12106498 adenosine Biochemical reaction from adenosine monophosphate to adenosine. This interaction is catalyzed by NT5E. tetrahydrofolic acid 5,10-methylenetetrahydrofolate Biochemical Reaction SHMT1 Gene malignant cell 19812215, 15797993 Biochemical reaction from tetrahydrofolic acid to 5,10-methylenetetrahydrofolate. This interaction is catalyzed by SHMT1. dihydrofolic acid tetrahydrofolic acid Biochemical Reaction DHFR Gene malignant cell 19812215, 14529544, 12084458 Biochemical reaction from dihydrofolic acid to tetrahydrofolic acid. This interaction is catalyzed by DHFR. 5,10-methylenetetrahydrofolate levomefolic acid Biochemical Reaction MTHFR Gene malignant cell 19812215, 15797993, 14647408 Biochemical reaction from 5,10-methylenetetrahydrofolate to levomefolic acid. This interaction is catalyzed by MTHFR. glycine l-serine Biochemical Reaction SHMT1 Gene malignant cell 19812215 Biochemical reaction from glycine to l-serine. This interaction is catalyzed by SHMT1. DNA methylated DNA Biochemical Reaction methyl transferases Gene Group malignant cell 19812215 Biochemical reaction from DNA to methylated DNA. This interaction is catalyzed by methyl transferases. dl-homocysteine cystathionine Biochemical Reaction CBS Gene malignant cell 19812215, 16013960 Biochemical reaction from homocysteine to cystathionine. This interaction is catalyzed by CBS. methionine s-adenosylmethionine Biochemical Reaction malignant cell 19812215 Biochemical reaction from methionine to s-adenosylmethionine. s-adenosylhomocysteine dl-homocysteine Biochemical Reaction malignant cell 19812215 Biochemical reaction from s-adenosylhomocysteine to homocysteine. levomefolic acid tetrahydrofolic acid Biochemical Reaction MTR, MTRR, cyanocobalamin Gene, Drug malignant cell 19812215 Biochemical reaction from levomefolic acid to tetrahydrofolic acid. This interaction can be catalyzed by cyanocobalamin, MTRR or MTR. dl-homocysteine methionine Biochemical Reaction MTR, MTRR, cyanocobalamin Gene, Drug malignant cell 19812215, 17611986, 15797993 Biochemical reaction from homocysteine to methionine. This interaction can be catalyzed by MTR, cyanocobalamin or MTRR. s-adenosylmethionine s-adenosylhomocysteine Biochemical Reaction methyl transferases Gene Group malignant cell 19812215 Biochemical reaction from s-adenosylmethionine to s-adenosylhomocysteine. This interaction is catalyzed by methyl transferases. methotrexate TYMS Inhibition malignant cell 12084458 TYMS methotrexate methotrexate inhibits TYMS. pemetrexed GART Inhibition malignant cell 16637794 GART pemetrexed pemetrexed inhibits GART. methotrexate PPAT Inhibition malignant cell 10432311 PPAT methotrexate methotrexate inhibits PPAT. pemetrexed DHFR Inhibition malignant cell 16637794 DHFR pemetrexed pemetrexed inhibits DHFR. Pyrimidine analogues TYMS Inhibition malignant cell 15638735, 12724731 TYMS Pyrimidine analogues inhibits TYMS. raltitrexed TYMS Inhibition malignant cell 12819937 TYMS raltitrexed raltitrexed inhibits TYMS. methotrexate DHFR Inhibition malignant cell 14662327, 12084458 DHFR methotrexate methotrexate inhibits DHFR. s-adenosylmethionine MTHFR Inhibition malignant cell 29891918 MTHFR s-adenosylmethionine inhibits MTHFR. ATIC ADA Inhibition malignant cell, cell 12106498 ADA, ATIC ATIC inhibits ADA. pemetrexed TYMS Inhibition malignant cell 16637794 TYMS pemetrexed pemetrexed inhibits TYMS. purine analogues PPAT Inhibition malignant cell 9744080, 5788533 PPAT purine analogues inhibits PPAT. methotrexate ATIC Inhibition malignant cell 27379764 ATIC methotrexate methotrexate inhibits ATIC. methotrexate GART Inhibition malignant cell 16637794 GART methotrexate methotrexate inhibits GART. purine nucleobase calabolic process inosine monophosphate Leads To malignant cell 28029518 purine nucleobase calabolic process leads to inosine monophosphate. 10-formyltetrahydrofolate purine nucleobase calabolic process Leads To ATIC, GART, PPAT Gene malignant cell 28029518, 16947783, 15457444, 14529544 10-formyltetrahydrofolate leads to purine nucleobase calabolic process. This interaction can be catalyzed by PPAT, ATIC or GART. DNA damage [MESH:D004249] apoptosis Leads To malignant cell 9096386 DNA damage [MESH:D004249] leads to apoptosis. deoxyuridine monophosphate DNA damage [MESH:D004249] Leads To malignant cell 9806758, 9096386 deoxyuridine monophosphate leads to DNA damage [MESH:D004249]. deoxythymidine monophosphate pyrimidine biosynthetic pathway Leads To malignant cell 16098809 deoxythymidine monophosphate leads to pyrimidine biosynthetic pathway.