pgkb.biopaxInteractionType==Catalysis
pgkb.reactionXrefDb==
pgkb.reactionName==
pgkb.reactionXrefId==
pgkb.lineStrength==Normal
Catalysis 79
Catalysis 79
pgkb.type==Gene
pgkb.role==NA
pgkb.state==NA
pgkb.cell==cell
RALBP1
RALBP1
vincristine
pgkb.type==Drug
PA451879
PharmGKB
pgkb.lineStrength==Major
pgkb.reactionXrefDb==
pgkb.reactionName==
pgkb.reactionXrefId==
pgkb.biopaxInteractionType==Biochemical Reaction
pgkb.isReversible==false
BiochemicalReaction Of vincristine To metabolite M1
BiochemicalReaction Of vincristine To metabolite M1
pgkb.geneComplexComponents==PA25269::BAX PA25302::BCL2
pgkb.cell==cell
pgkb.type==Gene Complex
BAX-BCL2
BAX-BCL2
pgkb.type==Gene
PA25302
PharmGKB
pgkb.type==Gene
pgkb.cell==cell
BCL2
BCL2
16620787
PubMed
pgkb.cell==na
pgkb.type==Drug
pgkb.prodrug==
vincristine
vincristine
pgkb.biopaxInteractionType==Inhibition
pgkb.reactionXrefDb==
pgkb.reactionName==
pgkb.reactionXrefId==
pgkb.lineStrength==Normal
Control_Inhibition 42
Control_Inhibition 42
created by katrin 08/25/10
pgkb.subId==PS206361
pgkb.classification==L::Antineoplastic And Immunomodulating Agents L01CA::Vinca alkaloids and analogues
pgkb.coe==PD::PD PK::PK
Vinka Alkaloid Pathway, Pharmacokinetics
Vinka Alkaloid Pathway, Pharmacokinetics
GO:0005622
Gene Ontology
pgkb.type==Gene Group
pgkb.state==NA
pgkb.memberGenes==
pgkb.cell==cell
tubulin
tubulin
BCL2
pgkb.reactionXrefDb==
pgkb.reactionName==
pgkb.biopaxInteractionType==Transport
pgkb.reactionXrefId==
pgkb.lineStrength==Normal
pgkb.isReversible==false
Transport Of vincristine To vincristine
Transport Of vincristine To vincristine
17442684
PubMed
pgkb.cell==liver cell
pgkb.type==Gene
pgkb.role==Secondary Metabolizing Enzyme
pgkb.state==NA
CYP3A4
CYP3A4
pgkb.reactionXrefDb==
pgkb.reactionName==
pgkb.reactionXrefId==
pgkb.lineStrength==Normal
pgkb.biopaxInteractionType==Biochemical Reaction
pgkb.isReversible==false
BiochemicalReaction Of BCL2 To BCL2
BiochemicalReaction Of BCL2 To BCL2
pgkb.biopaxInteractionType==Catalysis
pgkb.reactionXrefDb==
pgkb.reactionName==
pgkb.reactionXrefId==
pgkb.lineStrength==Normal
Catalysis 81
Catalysis 81
19118001
PubMed
pgkb.reactionXrefDb==
pgkb.reactionName==
pgkb.reactionXrefId==
pgkb.lineStrength==Normal
pgkb.biopaxInteractionType==Biochemical Reaction
pgkb.isReversible==false
BiochemicalReaction Of vincristine To metabolite M4
BiochemicalReaction Of vincristine To metabolite M4
17143522
PubMed
pgkb.cell==liver cell
pgkb.type==Gene
pgkb.role==NA
pgkb.state==NA
ABCC1
ABCC1
17272675
PubMed
18723777
PubMed
ABCB1
pgkb.type==Gene Complex
PA25269
PharmGKB
pgkb.type==Drug
pgkb.prodrug==
pgkb.cell==cell
vincristine
vincristine
pgkb.reactionXrefDb==
pgkb.reactionName==
pgkb.biopaxInteractionType==Transport
pgkb.reactionXrefId==
pgkb.lineStrength==Normal
pgkb.isReversible==false
Transport Of vincristine To vincristine
Transport Of vincristine To vincristine
pgkb.reactionXrefDb==
pgkb.reactionName==
pgkb.reactionXrefId==
pgkb.lineStrength==Normal
pgkb.biopaxInteractionType==Complex Assembly
pgkb.isReversible==false
ComplexAssembly Of BCL2 To BAX-BCL2
ComplexAssembly Of BCL2 To BAX-BCL2
Homo sapiens
pgkb.cell==liver cell
pgkb.type==Drug
pgkb.prodrug==
vincristine
vincristine
BAX
pgkb.biopaxInteractionType==Activation
pgkb.reactionXrefDb==
pgkb.reactionName==
pgkb.reactionXrefId==
pgkb.lineStrength==Normal
Control_Activation 86
Control_Activation 86
GO:0005576
Gene Ontology
pgkb.reactionXrefDb==
pgkb.reactionName==
pgkb.reactionXrefId==
pgkb.lineStrength==Normal
pgkb.biopaxInteractionType==Biochemical Reaction
pgkb.isReversible==false
BiochemicalReaction Of vincristine To metabolite M2
BiochemicalReaction Of vincristine To metabolite M2
pgkb.biopaxInteractionType==Catalysis
pgkb.reactionXrefDb==
pgkb.reactionName==
pgkb.reactionXrefId==
pgkb.lineStrength==Normal
Catalysis 93
Catalysis 93
pgkb.biopaxInteractionType==Catalysis
pgkb.reactionXrefDb==
pgkb.reactionName==
pgkb.reactionXrefId==
pgkb.lineStrength==Normal
Catalysis 91
Catalysis 91
ABCC3
15371983
PubMed
pgkb.type==Gene
PA130
PharmGKB
pgkb.cell==liver cell
pgkb.type==Gene
pgkb.role==NA
pgkb.state==NA
ABCB1
ABCB1
pgkb.type==Gene
PA131
PharmGKB
pgkb.reactionXrefDb==
pgkb.reactionName==
pgkb.biopaxInteractionType==Transport
pgkb.reactionXrefId==
pgkb.lineStrength==Normal
pgkb.isReversible==false
Transport Of vincristine To vincristine
Transport Of vincristine To vincristine
pgkb.biopaxInteractionType==Activation
pgkb.reactionXrefDb==
pgkb.reactionName==
pgkb.reactionXrefId==
pgkb.lineStrength==Normal
Control_Activation 82
Control_Activation 82
pgkb.type==Gene
pgkb.role==NA
pgkb.state==NA
pgkb.cell==cell
ABCC1
ABCC1
7753834
PubMed
pgkb.type==Gene
pgkb.role==NA
pgkb.state==NA
pgkb.cell==cell
BCL2
BCL2
16679390
PubMed
This is a black box pathway.
Microtubule Disruption
Black Box: Microtubule Disruption
pgkb.type==Gene
PA244
PharmGKB
pgkb.cell==liver cell
pgkb.type==Metabolite
pgkb.state==NA
metabolite M2
metabolite M2
Intracellular
15057285
PubMed
tubulin
pgkb.cell==liver cell
pgkb.type==Gene
pgkb.role==NA
pgkb.state==NA
ABCC2
ABCC2
pgkb.type==Gene
pgkb.cell==cell
BAX
BAX
pgkb.biopaxInteractionType==Inhibition
pgkb.reactionXrefDb==
pgkb.reactionName==
pgkb.reactionXrefId==
pgkb.lineStrength==Normal
Control_Inhibition 74
INHIBITION
Control_Inhibition 74
9823323
PubMed
ABCC10
ABCC1
pgkb.type==Gene
PA116
PharmGKB
GO:0005886
Gene Ontology
12851703
PubMed
pgkb.type==Gene
pgkb.role==NA
pgkb.state==NA
pgkb.cell==cell
ABCC10
ABCC10
pgkb.cell==liver cell
pgkb.type==Metabolite
pgkb.state==NA
metabolite M4
metabolite M4
ABCC2
pgkb.cell==na
pgkb.type==Drug
pgkb.prodrug==
vincristine
vincristine
RALBP1
9281595
PubMed
10501907
PubMed
pgkb.type==Gene
pgkb.role==NA
pgkb.state==NA
pgkb.cell==cell
ABCB1
ABCB1
pgkb.biopaxInteractionType==Catalysis
pgkb.reactionXrefDb==
pgkb.reactionName==
pgkb.reactionXrefId==
pgkb.lineStrength==Normal
Catalysis 49
Catalysis 49
pgkb.biopaxInteractionType==Inhibition
pgkb.reactionXrefDb==
pgkb.reactionName==
pgkb.reactionXrefId==
pgkb.lineStrength==Normal
Control_Inhibition 84
Control_Inhibition 84
pgkb.biopaxInteractionType==Catalysis
pgkb.reactionXrefDb==
pgkb.reactionName==
pgkb.reactionXrefId==
pgkb.lineStrength==Normal
Catalysis 47
Catalysis 47
pgkb.type==Gene
pgkb.role==NA
pgkb.state==NA
pgkb.cell==cell
ABCC2
ABCC2
http://pharmgkb.org
PharmGKB
PharmGKB
pgkb.type==Gene
pgkb.phosphatePosition==
pgkb.role==NA
pgkb.state==NA
pgkb.cell==cell
BCL2
BCL2
18408561
PubMed
9606
NCBI_Taxonomy
16883550
PubMed
pgkb.type==Gene
PA267
PharmGKB
pgkb.biopaxInteractionType==Catalysis
pgkb.reactionXrefDb==
pgkb.reactionName==
pgkb.reactionXrefId==
pgkb.lineStrength==Normal
Catalysis 30
Catalysis 30
Plasma Membrane
pgkb.type==Pathway
PA150981002
PharmGKB
pgkb.biopaxInteractionType==Catalysis
pgkb.reactionXrefDb==
pgkb.reactionName==
pgkb.reactionXrefId==
pgkb.lineStrength==Normal
Catalysis 32
Catalysis 32
pgkb.type==Gene
PA376
PharmGKB
CYP3A4
pgkb.type==Gene
PA34199
PharmGKB
pgkb.type==Gene
PA24392
PharmGKB
CYP3A5
pgkb.biopaxInteractionType==Activation
pgkb.reactionXrefDb==
pgkb.reactionName==
pgkb.reactionXrefId==
pgkb.lineStrength==Normal
Control_Activation 40
ACTIVATION
Control_Activation 40
pgkb.reactionXrefDb==
pgkb.reactionName==
pgkb.reactionXrefId==
pgkb.lineStrength==Normal
pgkb.biopaxInteractionType==Complex Assembly
pgkb.isReversible==false
ComplexAssembly Of vincristine To tubulin
ComplexAssembly Of vincristine To tubulin
pgkb.biopaxInteractionType==Catalysis
pgkb.reactionXrefDb==
pgkb.reactionName==
pgkb.reactionXrefId==
pgkb.lineStrength==Normal
Catalysis 60
Catalysis 60
pgkb.biopaxInteractionType==Catalysis
pgkb.reactionXrefDb==
pgkb.reactionName==
pgkb.reactionXrefId==
pgkb.lineStrength==Normal
Catalysis 64
Catalysis 64
pgkb.cell==liver cell
pgkb.type==Metabolite
pgkb.state==NA
metabolite M1
metabolite M1
pgkb.biopaxInteractionType==Catalysis
pgkb.reactionXrefDb==
pgkb.reactionName==
pgkb.reactionXrefId==
pgkb.lineStrength==Normal
Catalysis 62
Catalysis 62
pgkb.role==Primary Metabolizing Enzyme
pgkb.cell==liver cell
pgkb.type==Gene
pgkb.state==NA
CYP3A5
CYP3A5
pgkb.biopaxInteractionType==Catalysis
pgkb.reactionXrefDb==
pgkb.reactionName==
pgkb.reactionXrefId==
pgkb.lineStrength==Normal
Catalysis 69
Catalysis 69
metabolite M2
metabolite M1
pgkb.type==Gene
pgkb.role==NA
pgkb.state==NA
pgkb.cell==cell
ABCC3
ABCC3
metabolite M4
pgkb.biopaxInteractionType==Catalysis
pgkb.reactionXrefDb==
pgkb.reactionName==
pgkb.reactionXrefId==
pgkb.lineStrength==Normal
Catalysis 54
Catalysis 54
18650247
PubMed
This is a black box pathway.
Microtubule Polymerization
Black Box: Microtubule Polymerization
pgkb.biopaxInteractionType==Catalysis
pgkb.reactionXrefDb==
pgkb.reactionName==
pgkb.reactionXrefId==
pgkb.lineStrength==Normal
Catalysis 56
Catalysis 56
pgkb.biopaxInteractionType==Catalysis
pgkb.reactionXrefDb==
pgkb.reactionName==
pgkb.reactionXrefId==
pgkb.lineStrength==Normal
Catalysis 58
Catalysis 58
This is a black box pathway.
Apoptosis
Black Box: Apoptosis
Extracellular