PA27886
PharmGKB
pgkb.type==Gene
pgkb.lineStrength == Normal
pgkb.externalXrefDb ==
pgkb.biopaxInteractionType == Biochemical Reaction
pgkb.externalXrefId ==
pgkb.reactionName ==
Control_Biochemical Reaction 49
Control_Biochemical Reaction 49
11821457
PubMed
pgkb.state == NA
pgkb.cell == mammary epithelial cell
pgkb.type == Gene
pgkb.role == NA
ESR2
ESR2
ESR1
9748124
PubMed
pgkb.lineStrength == Normal
pgkb.externalXrefDb ==
pgkb.biopaxInteractionType == Biochemical Reaction
pgkb.externalXrefId ==
pgkb.reactionName ==
Control_Biochemical Reaction 53
Control_Biochemical Reaction 53
pgkb.lineStrength == Normal
pgkb.biopaxInteractionType == Catalysis
pgkb.externalXrefDb ==
pgkb.externalXrefId ==
pgkb.reactionName ==
Catalysis 41
Catalysis 41
pgkb.type == Biological Intermediate
pgkb.cell == cell
Estrone
Estrone
pgkb.biopaxInteractionType == Transport
pgkb.lineStrength == Normal
pgkb.externalXrefDb ==
pgkb.externalXrefId ==
pgkb.reactionName ==
Transport Of Estrone To Estrone
Transport Of Estrone To Estrone
Estrone
GO:0005622
Gene Ontology
pgkb.lineStrength == Normal
pgkb.externalXrefDb ==
pgkb.externalXrefId ==
pgkb.reactionName ==
pgkb.biopaxInteractionType == Inhibition
Control inhibition47
Control inhibition47
pgkb.type == Biological Intermediate
pgkb.cell == cell
Testosterone
Testosterone
PA156
PharmGKB
pgkb.type==Gene
INHIBITION
pgkb.lineStrength == Normal
pgkb.externalXrefDb ==
pgkb.externalXrefId ==
pgkb.reactionName ==
pgkb.biopaxInteractionType == Inhibition
Control_Inhibition 33
Control_Inhibition 33
pgkb.type == Biological Intermediate
pgkb.cell == cell
Estradiol
Estradiol
pgkb.lineStrength == Normal
pgkb.biopaxInteractionType == Catalysis
pgkb.externalXrefDb ==
pgkb.externalXrefId ==
pgkb.reactionName ==
Catalysis 43
Catalysis 43
letrozole
exemestane
PharmGKB
http://pharmgkb.org
PharmGKB
pgkb.lineStrength == Normal
pgkb.externalXrefDb ==
pgkb.biopaxInteractionType == Biochemical Reaction
pgkb.externalXrefId ==
pgkb.isReversible == false
pgkb.reactionName ==
BiochemicalReaction Of Testosterone To Estradiol
BiochemicalReaction Of Testosterone To Estradiol
9606
NCBI_Taxonomy
pgkb.state == NA
pgkb.cell == mammary epithelial cell
pgkb.type == Gene
pgkb.role == NA
ESR1
ESR1
pgkb.lineStrength == Normal
pgkb.externalXrefDb ==
pgkb.biopaxInteractionType == Biochemical Reaction
pgkb.isReversible == true
pgkb.externalXrefId ==
pgkb.reactionName ==
BiochemicalReaction Of Androstenedione To Testosterone
REVERSIBLE
BiochemicalReaction Of Androstenedione To Testosterone
This is a black box pathway.
ERE target genes
Black Box: ERE target genes
15939586
PubMed
14668813
PubMed
pgkb.lineStrength == Normal
pgkb.externalXrefDb ==
pgkb.externalXrefId ==
pgkb.reactionName ==
pgkb.biopaxInteractionType == Inhibition
Control inhibition51
Control inhibition51
pgkb.memberDrugs == PA448432::anastrozole PA449563::exemestane PA450196::letrozole
pgkb.cell == cell
pgkb.type == Drug Collection
letrozole
letrozole
anastrozole
pgkb.lineStrength == Normal
pgkb.externalXrefDb ==
pgkb.externalXrefId ==
pgkb.reactionName ==
pgkb.biopaxInteractionType == Inhibition
Control inhibition55
Control inhibition55
Testosterone
pgkb.biopaxInteractionType == Transport
pgkb.lineStrength == Normal
pgkb.externalXrefDb ==
pgkb.externalXrefId ==
pgkb.reactionName ==
Transport Of Estradiol To Estradiol
Transport Of Estradiol To Estradiol
12700178
PubMed
Homo sapiens
pgkb.memberDrugs == PA448432::anastrozole PA449563::exemestane PA450196::letrozole
pgkb.cell == cell
pgkb.type == Drug Collection
anastrozole
anastrozole
BiochemicalReaction Of CYP19A1 To CYP19A1
BiochemicalReaction Of CYP19A1 To CYP19A1
Androstenedione
pgkb.lineStrength == Normal
pgkb.externalXrefDb ==
pgkb.biopaxInteractionType == Biochemical Reaction
pgkb.externalXrefId ==
pgkb.isReversible == false
pgkb.reactionName ==
BiochemicalReaction Of Androstenedione To Estrone
BiochemicalReaction Of Androstenedione To Estrone
CYP19A1
GO:0005576
Gene Ontology
HSD17B1
pgkb.lineStrength == Normal
pgkb.biopaxInteractionType == Catalysis
pgkb.externalXrefDb ==
pgkb.externalXrefId ==
pgkb.reactionName ==
Catalysis 60
Catalysis 60
pgkb.lineStrength == Normal
pgkb.biopaxInteractionType == Catalysis
pgkb.externalXrefDb ==
pgkb.externalXrefId ==
pgkb.reactionName ==
Catalysis 23
Catalysis 23
pgkb.state == NA
pgkb.cell == cell
pgkb.type == Gene
pgkb.role == NA
CYP19A1
CYP19A1
pgkb.memberDrugs == PA448432::anastrozole PA449563::exemestane PA450196::letrozole
pgkb.cell == cell
pgkb.type == Drug Collection
exemestane
exemestane
pgkb.lineStrength == Normal
pgkb.biopaxInteractionType == Catalysis
pgkb.externalXrefDb ==
pgkb.externalXrefId ==
pgkb.reactionName ==
Catalysis 28
Catalysis 28
pgkb.lineStrength == Normal
pgkb.externalXrefDb ==
pgkb.biopaxInteractionType == Biochemical Reaction
pgkb.isReversible == true
pgkb.externalXrefId ==
pgkb.reactionName ==
BiochemicalReaction Of Estrone To Estradiol
REVERSIBLE
BiochemicalReaction Of Estrone To Estradiol
9828250
PubMed
pgkb.state == NA
pgkb.cell == cell
pgkb.type == Gene
pgkb.role == NA
CYP19A1
CYP19A1
PA448432
PharmGKB
pgkb.type==Drug Collection
pgkb.type == Biological Intermediate
pgkb.cell == mammary epithelial cell
Estrone
Estrone
pgkb.state == NA
pgkb.cell == cell
pgkb.type == Gene
pgkb.role == NA
HSD17B1
HSD17B1
pgkb.lineStrength == Normal
pgkb.biopaxInteractionType == Catalysis
pgkb.externalXrefDb ==
pgkb.externalXrefId ==
pgkb.reactionName ==
Catalysis 65
Catalysis 65
ESR2
pgkb.lineStrength == Normal
pgkb.externalXrefDb ==
pgkb.biopaxInteractionType == Biochemical Reaction
pgkb.externalXrefId ==
pgkb.reactionName ==
Control_Biochemical Reaction 70
Control_Biochemical Reaction 70
Estradiol
pgkb.type == Biological Intermediate
pgkb.cell == cell
Androstenedione
Androstenedione
pgkb.subId == PS206021
pgkb.coe ==
pgkb.classification ==
Aromatase Inhibitor Pathway (Breast Cell), Pharmacodynamics
Aromatase Inhibitor Pathway (Breast Cell), Pharmacodynamics
pgkb.lineStrength == Normal
pgkb.externalXrefDb ==
pgkb.biopaxInteractionType == Biochemical Reaction
pgkb.externalXrefId ==
pgkb.reactionName ==
BiochemicalReaction Of Estradiol To ER-mediated non-genomic effects
BiochemicalReaction Of Estradiol To ER-mediated non-genomic effects
PA449563
PharmGKB
pgkb.type==Drug Collection
pgkb.state == NA
pgkb.cell == cell
pgkb.type == Gene
pgkb.role == NA
HSD17B1
HSD17B1
pgkb.lineStrength == Normal
pgkb.externalXrefDb ==
pgkb.biopaxInteractionType == Biochemical Reaction
pgkb.externalXrefId ==
pgkb.reactionName ==
Control_Biochemical Reaction 45
Control_Biochemical Reaction 45
Intracellular
PA27091
PharmGKB
pgkb.type==Gene
pgkb.type == Biological Intermediate
pgkb.cell == mammary epithelial cell
Estradiol
Estradiol
PA145011120
PharmGKB
pgkb.type==null
pgkb.lineStrength == Normal
pgkb.externalXrefDb ==
pgkb.externalXrefId ==
pgkb.reactionName ==
pgkb.biopaxInteractionType == Inhibition
Control inhibition72
Control inhibition72
PA450196
PharmGKB
pgkb.type==Drug Collection
PA29478
PharmGKB
pgkb.type==Gene
Extracellular